C3)Drug dependence& drug abuse

"Opioids"

GR

🔹Tolerance..Due to adaptation of neurons

🔹pin point pupil may be misleaing

Because dilated pupils may occure due to CNS hypoxia

🔹Needle track is sign of acute on top of chronic opioid toxicity

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"Benzodiazepines"

🔹Benzodiazepine facilitate ال rape

"Cocaine "

🔹Cocaine cause perforation of nasal septum" End Module 2023"

1.Local anesthesia

2.Vasoconstriction

3.Irritants by adultrants

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ليه بستخدم X ray في ال drug dependence جت في الايند ٢٠٢٣ .

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سألت في ال volatile abuse في ال MCQ وكان سؤال غريب جدااا لأن معظم الناس مقرأتش السلايد ده حتى وكانت الاجابة عاوز أسمه اللي هو acetone تقريبا .

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في الفاينال جابت سؤال ريتن في ال anabolic steroids اللي مكنش متأكد عليها خالص وقال ليه بيحصل sudden cardiac death in young bodybuilders taking ASs .

"Benzodiazepines" GR🔹Benzodiazepine facilitate ال rape ?Because it is sedative , hypnotics and it is short acting drugs🔹 Contraindication mixed overdose with antidepressant or anti-asthmatic drugsDue to serious seizure may occure

"Opioids"GR🔹Tolerance.?Due to adaptation of neurons🔹pin point pupil may be misleaing ?Because dilated pupils may occure due to CNS hypoxia🔹 orthostatic hypotension?Due to peripheral vasodilation🔹flushed skin , urticaria?Due to histamine release🔹 Produce pulmonary edema ?Due to hypoxic alveolar damage🔹 Naloxone antidote take by infusion ?Due to the clinical half life of Naloxone is 20:60 min but the effect of opioids last for 12 hours

🔹anabolic steroids  couse  sudden cardiac death in young bodybuilders taking ASs ?Due to vasospasm effect of ASs produce myocardial infarction

🔹Do Chest x ray in opioids diagnosis? If pulmonary edema is suspected🔹Abdomenal x ray in opioids diagnosis?May be helpful when evaluating a suspected body stuffer ond body packer

" Amphetamines "🔹Couse renal infarction and cerebral infarction and myocardial ischemia ? Due to it's vasospasm effect on blood vessel🔹 Amphetamine couses rhabdomyolysis?Due to Direct toxic effect & vasospasm of BV & convulsions

🔹Cannabis withdrawal symptoms do not start before 5 to 10 days ?Due to cannabis supply continue at this time from the adipose tissue

"Cocaine "🔹Cocaine cause perforation of nasal septum"  End Module 2023"1.Local anesthesia2.continuous Vasoconstriction lead to ischemia then perforation 3.Irritantion by adultrants