✍ protein folding occur during protein production within the cell
✍ Alzheimer is the most common cause of dementia
✍ misfolded protein in Alzheimer is amyloid beta peptide
✍amyloid beta peptide precursor is amyloid precursor protein
✍ amyloid precursor protein has large extracellular glycosated N- terminus & short cytoplasmic C-terminus
✍ greatest risk factor of Alzheimer is Age ( >65 y)the risk doubles every 5 years
✍ amyloid beta peptide gene on chromosome 21
✍ presenilin 1 gene on chromosome 14
✍ presenilin 2 gene on chromosome 1
✍ Prion disease = spongiform encephalitis = Mad cow disease
✍ misfolded protein in Prion is prion protein
✍ Prion has a very long incubation period